Abstract
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What is the central question of this study?
Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation (HBO2) exposures on the outcome of cerebral tissue injury induced by a transient middle cerebral artery occlusion model in diabetic female rats? Are 20‐hydroxyeicosatetreanoic acid and epoxyeicosatrienoic acids involved?
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What is the main finding and its importance?
Equal reduction of cortical and total infarct size in rats treated with HBO2 and HET0016 (20‐hydroxyeicosatetreanoic acid production inhibitor) and significant mRNA upregulation of epoxyeicosatrienoic acid‐producing enzymes (Cyp2J3 and Cyp2C11) in treated groups suggest that HBO2 and HET0016 are highly effective stroke treatments and that cytochrome P450 metabolites are involved in this therapeutic effect.